smeltz2023.clint.L4: smeltz2023plasma;textualinvitroTKdata Intrinsic Hepatic Clearance Level-4 Data Set

Description

Bayesian estimate of intrinsic hepatic clearance (Clint) for cryopreserved pooled human hepatocytes. Chemicals were per- and polyfluoroalkyl substance (PFAS) samples. The experiments were led by Dr.s Marci Smeltz and Barbara Wetmore.

Usage

smeltz2023.clint.L4

Arguments

Format

A level-4 data.frame with 7 rows and 12 variables:

Compound.Name: Compound name
DTXSID: DSSTox Substance Identifier (CompTox Chemicals Dashboard)
Lab.Compound.Name: Compound as described in the laboratory
Clint.1.Med: Posterior median intrinsic hepatic clearance at 1 uM
Clint.1.Low: Posterior 2.5th quantile of intrinsic hepatic clearance at 1 uM (lower credible interval bound)
Clint.1.High: Posterior 97.5th quantile of intrinsic hepatic clearance at 1 uM (upper credible interval bound)
Clint.10.Med: Posterior median intrinsic hepatic clearance at 10 uM
Clint.10.Low: Posterior 2.5th quantile of intrinsic hepatic clearance at 10 uM (lower credible interval bound)
Clint.10.High: Posterior 97.5th quantile of intrinsic hepatic clearance at 10 uM (upper credible interval bound)
Clint.pValue: Probability that a chemical concentration decrease is observed
Sat.pValue: Probability that a lower Clint is observed at a higher concentration, i.e. saturation probability
degrades.pValue: Probability of abiotic degradation

References

shibata2002predictioninvitroTKdata

smeltz2023plasmainvitroTKdata