wambaugh2019.clint.L4

Bayesian estimate of intrinsic hepatic clearance
(Clint) measured using in vitro suspensions of pooled primary human
hepatocytes shibata2002predictioninvitroTKdata.

data

A collection of datasets containing a variety of in vitro toxicokinetic
measurements including -- but not limited to -- chemical fraction unbound
in the presence of plasma (f_up), intrinsic hepatic clearance (Clint,
uL/min/million hepatocytes), and membrane permeability for
oral absorption (Caco2). The datasets provided by the package were
processed and analyzed with the companion 'invitroTKstats' package.

Caroline Ring

invitroTKdata

In Vitro Toxicokinetic Data Processed with the 'invitroTKstats'
Pipeline

Sarah E. Davidson-Fritz

John Wambaugh

Lindsay Knupp

Barbara A. Wetmore

Anna Kreutz

Marci Smeltz

David Crizer

U.S. Federal Government 

wambaugh2019.clint.L4 function

A level-4 data.frame with 473 rows and 12 variables:<dl>
<dt><code>Compound.Name</code></dt>
<dd>Compound name</dd><dt><code>DTXSID</code></dt>
<dd>DSSTox Substance Identifier (CompTox Chemicals Dashboard)</dd><dt><code>Lab.Compound.Name</code></dt>
<dd>Compound as described in the laboratory</dd><dt><code>Clint.1.Med</code></dt>
<dd>Posterior median intrinsic hepatic clearance at 1 uM</dd><dt><code>Clint.1.Low</code></dt>
<dd>Posterior 2.5th quantile of intrinsic hepatic clearance at 1 uM (lower credible interval bound)</dd><dt><code>Clint.1.High</code></dt>
<dd>Posterior 97.5th quantile of intrinsic hepatic clearance at 1 uM (upper credible interval bound)</dd><dt><code>Clint.10.Med</code></dt>
<dd>Posterior median intrinsic hepatic clearance at 10 uM</dd><dt><code>Clint.10.Low</code></dt>
<dd>Posterior 2.5th quantile of intrinsic hepatic clearance at 10 uM (lower credible interval bound)</dd><dt><code>Clint.10.High</code></dt>
<dd>Posterior 97.5th quantile of intrinsic hepatic clearance at 10 uM (upper credible interval bound)</dd><dt><code>Clint.pValue</code></dt>
<dd>Probability that a chemical concentration decrease is observed</dd><dt><code>Sat.pValue</code></dt>
<dd>Probability that a lower <code>Clint</code> is observed at a higher concentration, i.e. saturation probability</dd><dt><code>degrades.pValue</code></dt>
<dd>Probability of abiotic degradation</dd>
</dl>

Format

wambaugh2019assessing;textualinvitroTKdata Intrinsic Hepatic Clearance Level-4 Data Set — wambaugh2019.clint.L4

A level-4 data.frame with 473 rows and 12 variables:<dl>
<dt><code>Compound.Name</code></dt>
<dd>Compound name</dd>

<dt><code>DTXSID</code></dt>
<dd>DSSTox Substance Identifier (CompTox Chemicals Dashboard)</dd>

<dt><code>Lab.Compound.Name</code></dt>
<dd>Compound as described in the laboratory</dd>

<dt><code>Clint.1.Med</code></dt>
<dd>Posterior median intrinsic hepatic clearance at 1 uM</dd>

<dt><code>Clint.1.Low</code></dt>
<dd>Posterior 2.5th quantile of intrinsic hepatic clearance at 1 uM (lower credible interval bound)</dd>

<dt><code>Clint.1.High</code></dt>
<dd>Posterior 97.5th quantile of intrinsic hepatic clearance at 1 uM (upper credible interval bound)</dd>

<dt><code>Clint.10.Med</code></dt>
<dd>Posterior median intrinsic hepatic clearance at 10 uM</dd>

<dt><code>Clint.10.Low</code></dt>
<dd>Posterior 2.5th quantile of intrinsic hepatic clearance at 10 uM (lower credible interval bound)</dd>

<dt><code>Clint.10.High</code></dt>
<dd>Posterior 97.5th quantile of intrinsic hepatic clearance at 10 uM (upper credible interval bound)</dd>

<dt><code>Clint.pValue</code></dt>
<dd>Probability that a chemical concentration decrease is observed</dd>

<dt><code>Sat.pValue</code></dt>
<dd>Probability that a lower <code>Clint</code> is observed at a higher concentration, i.e. saturation probability</dd>

<dt><code>degrades.pValue</code></dt>
<dd>Probability of abiotic degradation</dd>


</dl>

wambaugh2019assessing;textualinvitroTKdata Intrinsic Hepatic Clearance Level-4 Data Set

wambaugh2019.clint.L4: wambaugh2019assessing;textualinvitroTKdata Intrinsic Hepatic Clearance Level-4 Data Set

Description

Usage

Arguments

Format

References