wambaugh2019.red.L3

Frequentist estimate of plasma protein binding using the rapid equilibrium
dialysis (RED) assay method waters2008validationinvitroTKdata.

data

A collection of datasets containing a variety of in vitro toxicokinetic
measurements including -- but not limited to -- chemical fraction unbound
in the presence of plasma (f_up), intrinsic hepatic clearance (Clint,
uL/min/million hepatocytes), and membrane permeability for
oral absorption (Caco2). The datasets provided by the package were
processed and analyzed with the companion 'invitroTKstats' package.

Caroline Ring

invitroTKdata

In Vitro Toxicokinetic Data Processed with the 'invitroTKstats'
Pipeline

Sarah E. Davidson-Fritz

John Wambaugh

Lindsay Knupp

Barbara A. Wetmore

Anna Kreutz

Marci Smeltz

David Crizer

U.S. Federal Government 

wambaugh2019.red.L3 function

A data.frame 368 rows and 4 variables:<dl>
<dt><code>Compound.Name</code></dt>
<dd>Compound name</dd><dt><code>DTXSID</code></dt>
<dd>DSSTox Substance Identifier (CompTox Chemicals Dashboard)</dd><dt><code>Calibration</code></dt>
<dd>Identifier for mass spectrometry calibration - usually the date</dd><dt><code>Fup</code></dt>
<dd>Frequentist point estimate for fraction unbound in plasma (fup)</dd>
</dl>

Format

wambaugh2019assessing;textualinvitroTKdata Rapid Equilibrium Dialysis Level-3 Data Set — wambaugh2019.red.L3

A data.frame 368 rows and 4 variables:<dl>
<dt><code>Compound.Name</code></dt>
<dd>Compound name</dd>

<dt><code>DTXSID</code></dt>
<dd>DSSTox Substance Identifier (CompTox Chemicals Dashboard)</dd>

<dt><code>Calibration</code></dt>
<dd>Identifier for mass spectrometry calibration - usually the date</dd>

<dt><code>Fup</code></dt>
<dd>Frequentist point estimate for fraction unbound in plasma (fup)</dd>


</dl>

wambaugh2019assessing;textualinvitroTKdata Rapid Equilibrium Dialysis Level-3 Data Set

wambaugh2019.red.L3: wambaugh2019assessing;textualinvitroTKdata Rapid Equilibrium Dialysis Level-3 Data Set

Description

Usage

Arguments

Format

References