plot_clint

This function generates a response-versus-time plot of mass spectrometry (MS) 
responses collected from measurements of intrinsic hepatic clearance for a chemical.
Responses from different measurements/calibrations are labeled with different colors, 
and responses from various sample types are labeled with different shapes.

A set of tools for processing and analyzing in vitro toxicokinetic
measurements in a standardized and reproducible pipeline. The package
was developed to perform frequentist and Bayesian estimation on a
variety of in vitro toxicokinetic measurements including -- but not
limited to -- chemical fraction unbound in the presence of plasma
(f_up), intrinsic hepatic clearance (Clint,
uL/min/million hepatocytes), and membrane permeability for
oral absorption (Caco2). The methods provided
by the package were described in Wambaugh et al. (2019) <doi:10.1093/toxsci/kfz205>.

Caroline Ring

invitroTKstats

In Vitro Toxicokinetic Data Processing and Analysis Pipeline

John Wambaugh

Sarah E. Davidson-Fritz

Lindsay Knupp

Barbara A. Wetmore

Zhao Zhihui

Chantel Nicolas

Anna Kreutz

U.S. Federal Government 

plot_clint function

<dl><dt>level2</dt>
<dd>(Data Frame) A data frame containing level-2 data with a measure
of chemical clearance over time when incubated with suspended hepatocytes.</dd>
<dt>dtxsid</dt>
<dd>(Character) EPA's DSSTox Structure ID for the chemical to be plotted.</dd>
<dt>color.palette</dt>
<dd>(Character) A character string indicating which 
<code>viridis</code> R package color map option to use. (Defaults to "viridis".)</dd></dl>

Arguments

Author

Plot Mass Spectrometry Responses from Measurements of Intrinsic
Hepatic Clearance — plot_clint

<dl>

<dt>level2</dt>
<dd>(Data Frame) A data frame containing level-2 data with a measure
of chemical clearance over time when incubated with suspended hepatocytes.</dd>


<dt>dtxsid</dt>
<dd>(Character) EPA's DSSTox Structure ID for the chemical to be plotted.</dd>


<dt>color.palette</dt>
<dd>(Character) A character string indicating which 
<code>viridis</code> R package color map option to use. (Defaults to "viridis".)</dd>

</dl>

Plot Mass Spectrometry Responses from Measurements of Intrinsic
Hepatic Clearance

plot_clint: Plot Mass Spectrometry Responses from Measurements of Intrinsic Hepatic Clearance

Description

Usage

Value

Arguments

Author

Details

Examples