Calculate area under the plasma concentration vs. time curve for the 2-compartment model, using an analytical equation (the integral of the 2-compartment model equation with respect to time).
auc_2comp(params, time, dose, route, medium = "plasma")A vector of plasma AUC values, evaluated at each time point in `time`.
A named list of parameter values.
A numeric vector of time values, in hours
A numeric vector of doses in mg/kg
A logical vector: TRUE for single IV bolus dose, FALSE for single oral dose
A character string that determines the measured media. Default: "plasma".
`params` must include the following named items:
Rate at which the compound moves from the central to peripheral compartment, 1/h.
Rate at which the compound moves from peripheral to central compartment, 1/h.
Elimination rate, 1/h.
Apparent volume of central compartment, L/kg BW.
For oral administration (route FALSE), params must also include:
Oral bioavailability, unitless fraction.
rate of absorption from gut, 1/h.
For oral administration, in lieu of "V1" and "Fgutabs", you may instead provide "Fgutabs_V1", the ratio of Fgutabs to V1 (1/L). This is an alternate parameterization for situations where "Fgutabs" and "V1" are not identifiable separately (i.e. when oral data are available, but IV data are not). If "Fgutabs" and "V1" are provided, then "Fgutabs_V1" will not be used.
Caroline Ring, John Wambaugh
Other built-in model functions:
auc_1comp(),
auc_flat(),
auc_httk_gas_pbtk(),
cp_1comp(),
cp_2comp(),
cp_2comp_dt(),
cp_flat(),
cp_httk_gas_pbtk(),
get_params_1comp(),
get_params_2comp(),
get_params_flat(),
get_params_httk_gas_pbtk(),
get_starts_1comp(),
get_starts_2comp(),
get_starts_flat(),
get_starts_httk_gas_pbtk(),
tkstats_2comp(),
transformed_params_2comp()
Other 2-compartment model functions:
cp_2comp(),
cp_2comp_dt(),
get_params_2comp(),
get_starts_2comp(),
tkstats_2comp(),
transformed_params_2comp()
Other model AUC functions:
auc_1comp(),
auc_flat()