auc_httk_gas_pbtk: Calculates AUC for `httk`'s `gas_pbtk` PBPK model

Description

Calculated plasma concentration AUC vs time according to the `gas_pbtk`

Usage

auc_httk_gas_pbtk(
  params,
  time,
  dose,
  route,
  medium = "plasma",
  this_chem = NULL,
  this_species = NULL,
  restrictive = TRUE
)

Value

A vector of blood or plasma AUC values corresponding to `time`.

Arguments

params: A named numeric vector of model parameter values.
time: A numeric vector of times, reflecting the time point when concentration is measured after the corresponding single bolus dose. Must be same length as `dose` and `iv.dose`, or length 1.
dose: A numeric vector of doses, reflecting single bolus doses administered at time 0. Must be same length as `time` and `iv.dose`, or length 1. In this model, it is expected that this value represents a measurement of radioactive particles from a radiolabeling experiment.
route: A character vector, reflecting the route of administration of each single bolus dose: `'oral'` or `'iv'`. Must be same length as `time` and `dose`, or length 1.
medium: A character vector reflecting the medium in which each resulting concentration is to be calculated: "blood" or "plasma". Default is "plasma". Must be same length as `time` and `dose`, or length 1.
this_chem: A character vector naming the chemical for calculations in `httk`.
this_species: A character vector naming the species for calculations in `httk`.
restrictive: A logical value (TRUE or FALSE. Default: FALSE) that says whether the assumption is that the clearance is restrictive or non-restrictive

Required parameters

These are given by [httk::parameterize_gas_pbtk()]. Furthermore, they are transformed to a vector during the prefitting process. The optimized parameters are `Clint` and `Funbound.plasma`. Because these optimized parameters impact `Clmetabolismc`, `Krbc2pu`, `Rblood2plasma` and `Fabsgut`, these are recalculated at the beginning of this function.

Author