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invivoPKfit (version 2.0.2)

model_httk_gas_pbtk: Gas pbtk `httk` model

Description

The `pk_model` object defining the "gas_pbtk" model from `httk`, with recalculations of other "constant" parameters that depend on optimized parameters.

Usage

model_httk_gas_pbtk

Arguments

Format

An object of class list (inherits from pk_model) of length 12.

Details

A `pk_model` object: under the hood, a `list` object with named elements corresponding to the arguments of [pk_model()]. The default set of parameters to optimize are `Clint` and `Funbound.plasma`, but users can also fit partition coefficients. Note that fitting may present instability during ODE solving step. See that function documentation for the definition of each element.

See [cp_httk_gas_pbtk()] for the function that predicts blood/plasma concentration for a bolus dose (oral or IV).

See [get_params_httk_gas_pbtk()] for the function that determines bounds and starting guesses for model parameters, based on the data.