Creating a simple test CvT dataset
pseudo_cvt(
params = c(Clint = 10, Q_gfr = 0.31, Q_totli = 0.743, Fup = 0.2, Vdist = 1.2, Fgutabs =
0.75, kgutabs = 0.3, Rblood2plasma = 0.8, Frec = 0.95),
time = seq(0, 30, by = 0.5),
dose = 100,
route = c("oral", "iv"),
medium = c("blood", "plasma", "excreta"),
N = 4,
var = 0.5
)A data frame with concentration over time data.
A named numeric vector of model parameter values.
A numeric vector of times, reflecting the time point when concentration is measured after the corresponding single bolus dose. Must be same length as `dose` and `iv.dose`, or length 1.
A numeric vector of doses, reflecting single bolus doses administered at time 0. Must be same length as `time` and `iv.dose`, or length 1. In this model, it is expected that this value represents a measurement of radioactive particles from a radiolabeling experiment.
A character vector, reflecting the route of administration of each single bolus dose: `'oral'` or `'iv'`. Must be same length as `time` and `dose`, or length 1.
A character vector reflecting the medium in which each resulting concentration is to be calculated: "blood" or "plasma". Default is "plasma". Must be same length as `time` and `dose`, or length 1.
Numeric, positive and non-zero integer. Number of individual subjects.
Numeric between 0 and 1. Describes variation in the measurements.