epileptic.qol: Quality of life data following epilepsy drug treatment
Description
The SANAD (Standard and New Antiepileptic Drugs) study (Marson
et al., 2007) is a randomised control trial of standard and new
antiepileptic drugs, comparing effects on longer term clinical outcomes.
Quality of life (QoL) data were collected by mail at baseline, 3 months,
and at 1 and 2 years using validated measures. This data is a subset of the
trial for 544 patients randomised to one of 2 drugs: carbamazepine and
lamotrigine.Format
A data frame with 1853 observations on the following 9 variables:
id- patients identifier; in total there are 544 patients.
fuyears- number of years between registration and the earlier
of treatment failure or study analysis time.
trt- a factor with levels
CBZ and LTG denoting
carbamazepine and lamotrigine, respectively. status- the reason for treatment failure. Coded as
0 = censored; 1 = unacceptable adverse effects;
2 = inadequate seizure control. time- the time the quality of life measures were recorded
(days). The first measurement for each subject is the baseline measurement,
however there was variability between the time taken to return the
questionnaires; hence the reason this is non-zero. Similarly, the second,
third, and fourth follow-up times, which were scheduled for 3-months,
1-year, and 2-years, respectively, also had variability in completion
times.
anxiety- a continuous measure of anxiety, as defined according
to the NEWQOL (Newly Diagnosed Epilepsy Quality of Life) assessment. Higher
scores are indicative of worse QoL.
depress- a continuous measure of depression, as defined
according to the NEWQOL (Newly Diagnosed Epilepsy Quality of Life)
assessment. Higher scores are indicative of worse QoL.
aep- a continuous measure of the Liverpool Adverse Events
Profile (AEP), as defined according to the NEWQOL (Newly Diagnosed Epilepsy
Quality of Life) assessment. Higher scores are indicative of worse QoL.
status2- a binary indicator of composite treatment failure
(for any reason), coded
status2 = 1, or right-censoring
status2 = 0.
References
Jacoby A, Sudell M, Tudur Smith C, et al. Quality-of-life outcomes of
initiating treatment with standard and newer antiepileptic drugs in adults
with new-onset epilepsy: Findings from the SANAD trial. Epilepsia.
2015; 56(3): 460-472. Marson AG, Appleton R, Baker GA, et al. A randomised controlled trial
examining longer-term outcomes of standard versus new antiepileptic drugs.
The SANAD Trial. Health Technology Assessment. 2007; 11(37). Marson AG, Al-Kharusi AM, Alwaidh M, et al. The SANAD study of effectiveness
of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for
treatment of partial epilepsy: an unblinded randomised controlled trial.
Lancet. 2007; 365: 2007-2013. Abetz L, Jacoby A, Baker GA, et al. Patient-based assessments of quality of
life in newly diagnosed epilepsy patients: validation of the NEWQOL.
Epilepsia. 2000; 41: 1119-1128.