pbc2: Mayo Clinic primary biliary cirrhosis data
Description
This data is from the Mayo Clinic trial in primary biliary
cirrhosis (PBC) of the liver conducted between 1974 and 1984. A total of
424 PBC patients, referred to Mayo Clinic during that ten-year interval met
eligibility criteria for the randomized placebo controlled trial of the
drug D-penicillamine, but only the first 312 cases in the data set
participated in the randomized trial. Therefore, the data here are for the
312 patients with largely complete data.Format
A data frame with 1945 observations on the following 20 variables:
id- patients identifier; in total there are 312 patients.
years- number of years between registration and the earlier of
death, transplantation, or study analysis time.
status- a factor with levels
alive, transplanted
and dead. drug- a factor with levels
placebo and
D-penicil. age- at registration in years.
sex- a factor with levels
male and female. year- number of years between enrollment and this visit date,
remaining values on the line of data refer to this visit.
ascites- a factor with levels
No and Yes. hepatomegaly- a factor with levels
No and Yes. spiders- a factor with levels
No and Yes. edema- a factor with levels
No edema (i.e. no edema and
no diuretic therapy for edema), edema no diuretics (i.e. edema
present without diuretics, or edema resolved by diuretics), and edema
despite diuretics (i.e. edema despite diuretic therapy). serBilir- serum bilirubin in mg/dl.
serChol- serum cholesterol in mg/dl.
albumin- albumin in mg/dl.
alkaline- alkaline phosphatase in U/liter.
SGOT- SGOT in U/ml.
platelets- platelets per cubic ml/1000.
prothrombin- prothrombin time in seconds.
histologic- histologic stage of disease.
status2- a numeric vector with the value 1 denoting if the
patient was dead, and 0 if the patient was alive or transplanted.
References
Fleming T, Harrington D. Counting Processes and Survival Analysis.
1991; New York: Wiley. Therneau T, Grambsch P. Modeling Survival Data: Extending the Cox
Model. 2000; New York: Springer-Verlag.