renal: Renal transplantation data
Description
This is a dataset on 407 patients suffering from chronic kidney
disease who underwent a primary renal transplantation with a graft from a
deceased or living donor in the University Hospital of the Catholic
University of Leuven (Belgium) between 21 January 1983 and 16 August 2000.
Chronic kidney (renal) disease is a progressive loss of renal function over
a period of months or years through five stages. Each stage is a
progression through an abnormally low and progressively worse glomerular
filtration rate (GFR). The dataset records 3 repeated measures (2
continuous and 1 binary), and an event time.Format
This is a list with 4 data frames:
prot: repeated measurement data for proteinuria (binary) that
measures whether the kidneys succeed in sustaining the proteins in the
blood and not discard them in the urine. haem: repeated measurement data for blood haematocrit level
(continuous) that measures whether the kidneys produce adequate amounts of
the hormone erythropoietin that regulates the red blood cell production. gfr: repeated measurement data for GFR (continuous) that
measures the filtration rate of the kidneys. surv: time-to-event data for renal graft failure.
All datasets have the common data columns, which are in long
format for the 3 longitudinal data data frames, and 1-per-subject for the
time-to-event data frame: id- number for patient identification.
age- age of patient at day of surgery (years).
weight- preoperative weight of patient (kg).
sex- gender of patient.
fuyears- maximum follow up time, with transplant date as the
time origin (years).
failure- censoring indicator (
1 = graft failure and
0 = censored).
The longitudinal datasets only contain 2 further columns:
time- observed time point, with surgery date as the time
origin (years).
- biomarker value
- a recorded measurement of the biomarker taken at
time
time. The 3 biomarkers (one per data frame) are:
proteinuria: recorded as binary indicator: present or
not-present. Present in the prot data. haematocrit: recorded as percentage (%) of the ratio of the
volume of red blood cells to the total volume of blood. Present in the
haem data. gfr: measured as ml/min/1.73m\(^2\). Present in the
gfr data.
References
Rizopoulos D, Ghosh, P. A Bayesian semiparametric multivariate joint model
for multiple longitudinal outcomes and a time-to-event. Stat Med.
2011; 30(12): 1366-80.