joineRML-package

Fits the joint model proposed by Henderson and colleagues (2000) tools:::Rd_expr_doi("10.1093/biostatistics/1.4.465"), but extended to the case of multiple continuous longitudinal measures. The time-to-event data is modelled using a Cox proportional hazards regression model with time-varying covariates. The multiple longitudinal outcomes are modelled using a multivariate version of the Laird and Ware linear mixed model. The association is captured by a multivariate latent Gaussian process. The model is estimated using a Monte Carlo Expectation Maximization algorithm. This project was funded by the Medical Research Council (Grant number MR/M013227/1).

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Fits the joint model proposed by Henderson and colleagues (2000)
<doi:10.1093/biostatistics/1.4.465>, but extended to the case of multiple
continuous longitudinal measures. The time-to-event data is modelled using a
Cox proportional hazards regression model with time-varying covariates. The
multiple longitudinal outcomes are modelled using a multivariate version of the
Laird and Ware linear mixed model. The association is captured by a multivariate
latent Gaussian process. The model is estimated using a Monte Carlo Expectation
Maximization algorithm. This project was funded by the Medical Research Council
(Grant number MR/M013227/1).

Hickey Graeme L.

joineRML

Joint Modelling of Multivariate Longitudinal Data and
Time-to-Event Outcomes

Graeme L. Hickey

Pete Philipson

Andrea Jorgensen

Ruwanthi Kolamunnage-Dona

Paula Williamson

Dimitris Rizopoulos

Alessandro Gasparini

Medical Research Council 

joineRML-package function

Maintainer: Graeme L. Hickey <a href="/link/graemeleehickey%40gmail.com?package=joineRML&version=0.4.8" data-mini-rdoc="joineRML::graemeleehickey@gmail.com">graemeleehickey@gmail.com</a> (<a href="https://orcid.org/0000-0002-4989-0054">ORCID</a>)
Authors:<ul>
<li>Pete Philipson <a href="/link/peter.philipson1%40newcastle.ac.uk?package=joineRML&version=0.4.8" data-mini-rdoc="joineRML::peter.philipson1@newcastle.ac.uk">peter.philipson1@newcastle.ac.uk</a> (<a href="https://orcid.org/0000-0001-7846-0208">ORCID</a>)</li>
<li>Ruwanthi Kolamunnage-Dona <a href="/link/kdrr%40liverpool.ac.uk?package=joineRML&version=0.4.8" data-mini-rdoc="joineRML::kdrr@liverpool.ac.uk">kdrr@liverpool.ac.uk</a> (<a href="https://orcid.org/0000-0003-3886-6208">ORCID</a>)</li>
<li>Alessandro Gasparini <a href="/link/alessandro.gasparini%40ki.se?package=joineRML&version=0.4.8" data-mini-rdoc="joineRML::alessandro.gasparini@ki.se">alessandro.gasparini@ki.se</a> (<a href="https://orcid.org/0000-0002-8319-7624">ORCID</a>)</li>
</ul>Other contributors:<ul>
<li>Andrea Jorgensen <a href="/link/aljorgen%40liverpool.ac.uk?package=joineRML&version=0.4.8" data-mini-rdoc="joineRML::aljorgen@liverpool.ac.uk">aljorgen@liverpool.ac.uk</a> (<a href="https://orcid.org/0000-0002-6977-9337">ORCID</a>) [contributor]</li>
<li>Paula Williamson <a href="/link/p.r.williamson%40liverpool.ac.uk?package=joineRML&version=0.4.8" data-mini-rdoc="joineRML::p.r.williamson@liverpool.ac.uk">p.r.williamson@liverpool.ac.uk</a> (<a href="https://orcid.org/0000-0001-9802-6636">ORCID</a>) [contributor]</li>
<li>Dimitris Rizopoulos <a href="/link/d.rizopoulos%40erasmusmc.nl?package=joineRML&version=0.4.8" data-mini-rdoc="joineRML::d.rizopoulos@erasmusmc.nl">d.rizopoulos@erasmusmc.nl</a> (data/renal.rda, R/hessian.R, R/vcov.R) [contributor, data contributor]</li>
<li>Medical Research Council (Grant number: MR/M013227/1) [funder]</li>
</ul>

Author

joineRML: Joint Modelling of Multivariate Longitudinal Data and Time-to-Event Outcomes — joineRML-package

Maintainer: Graeme L. Hickey <a href='mailto:graemeleehickey@gmail.com'>graemeleehickey@gmail.com</a> (<a href='https://orcid.org/0000-0002-4989-0054'>ORCID</a>)
Authors:<ul>
<li>Pete Philipson <a href='mailto:peter.philipson1@newcastle.ac.uk'>peter.philipson1@newcastle.ac.uk</a> (<a href='https://orcid.org/0000-0001-7846-0208'>ORCID</a>)</li>
<li>Ruwanthi Kolamunnage-Dona <a href='mailto:kdrr@liverpool.ac.uk'>kdrr@liverpool.ac.uk</a> (<a href='https://orcid.org/0000-0003-3886-6208'>ORCID</a>)</li>
<li>Alessandro Gasparini <a href='mailto:alessandro.gasparini@ki.se'>alessandro.gasparini@ki.se</a> (<a href='https://orcid.org/0000-0002-8319-7624'>ORCID</a>)</li>
</ul>

Other contributors:<ul>
<li>Andrea Jorgensen <a href='mailto:aljorgen@liverpool.ac.uk'>aljorgen@liverpool.ac.uk</a> (<a href='https://orcid.org/0000-0002-6977-9337'>ORCID</a>) [contributor]</li>
<li>Paula Williamson <a href='mailto:p.r.williamson@liverpool.ac.uk'>p.r.williamson@liverpool.ac.uk</a> (<a href='https://orcid.org/0000-0001-9802-6636'>ORCID</a>) [contributor]</li>
<li>Dimitris Rizopoulos <a href='mailto:d.rizopoulos@erasmusmc.nl'>d.rizopoulos@erasmusmc.nl</a> (data/renal.rda, R/hessian.R, R/vcov.R) [contributor, data contributor]</li>
<li>Medical Research Council (Grant number: MR/M013227/1) [funder]</li>
</ul>

joineRML: Joint Modelling of Multivariate Longitudinal Data and Time-to-Event Outcomes

joineRML-package: joineRML: Joint Modelling of Multivariate Longitudinal Data and Time-to-Event Outcomes

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Author

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