kangar00 (version 1.1)

make_psd,matrix-method: Adjust network matrix to be positive semi-definite

Description

Adjust network matrix to be positive semi-definite

Usage

# S4 method for matrix
make_psd(x, eps = sqrt(.Machine$double.eps))

Arguments

x

A matrix specifying the network adjacency matrix.

eps

A numeric value, setting the tolance for smallest eigenvalue adjustment

Value

The matrix x, if it is positive definite and the closest positive semi-definite matrix if x is not positive semi-definite.

Details

For a matrix N, the closest positive semi-definite matrix is calculated as N* = rho*N + (1+rho)*I, where I is the identity matrix and rho = 1/(1 - lambda) with lambda the smallest eigenvalue of N. For more details check the references.

References

• Freytag S, Manitz J, Schlather M, Kneib T, Amos CI, Risch A, Chang-Claude J, Heinrich J, Bickeboeller H: A network-based kernel machine test for the identification of risk pathways in genome-wide association studies. Hum Hered. 2013, 76(2):64-75.