lcmm-package: Estimation of Latent Class Mixed Models and Joint Latent Class Mixed Models for quantitative, bounded quantitative, discrete and ordinal longitudinal outcomes and a right-censored left-truncated time-to-event.

Description

This package provides functions for the estimation of latent class mixed models (LCMM) and joint latent class mixed models using a maximum likelihood method.

Arguments

Details

ll{ Package: lcmm Type: Package Version: 1.4-3 Date: 2011-01-13 License: GPL (>=2.0) LazyLoad: yes } The package includes for the moment the estimation of latent class mixed models for Gaussian longitudinal outcomes using hlme function, and for other quantitative, bounded quantitative and discrete longitudinal outcomes using lcmm function, and joint latent class mixed model for Gaussian longitudinal outcome and a time-to-event using Jointlcmm function.

Please report to the maintainer any bug or comment regarding the package for future updates.

References

Lin, Turnbull, McCulloch and Slate (2002). Latent class models for joint analysis of longitudinal biomarker and event process data: application to longitudinal prostate-specific antigen readings and prostate cancer. Journal of the American Statistical Association 97, 53-65.

Muthen and Shedden (1999). Finite mixture modeling with mixture outcomes using the EM algorithm. Biometrics 55, 463-9

Proust and Jacqmin-Gadda (2005). Estimation of linear mixed models with a mixture of distribution for the random-effects. Comput Methods Programs Biomed 78:165-73

Proust, Jacqmin-Gadda, Taylor, Ganiayre, and Commenges (2006). A nonlinear model with latent process for cognitive evolution using multivariate longitudinal data. Biometrics 62, 1014-24.

Proust-Lima, Dartigues, and Jacqmin-Gadda (2011). Misuse of the linear mixed model when evaluating risk factors of cognitive decline. Amer J Epidemiol - in press

Proust-Lima and Taylor (2009). Development and validation of a dynamic prognostic tool for prostate cancer recurrence using repeated measures of post-treatment PSA: a joint modelling approach. Biostatistics 10, 535-49.

Verbeke and Lesaffre (1996). A linear mixed-effects model with heterogeneity in the random-effects population. Journal of the American Statistical Association 91, 217-21