generateETA

Generate individual random effects from a multivariate normal distribution.

Generate concentration-time profiles from linear pharmacokinetic
(PK) systems, possibly with first-order absorption or zero-order infusion,
possibly with one or more peripheral compartments, and possibly under
steady-state conditions. Single or multiple doses may be specified. Secondary
(derived) PK parameters (e.g. Cmax, Ctrough, AUC, Tmax, half-life, etc.) are
computed.

Benjamin Rich

linpk

Generate Concentration-Time Profiles from Linear PK Systems

generateETA function

<dl><dt>n</dt>
<dd>The number of individuals.</dd>
<dt>omegaLT</dt>
<dd>A numeric vector giving the elements of the lower triangle
of the covariance matrix by row.</dd>
<dt>omega</dt>
<dd>The covariance matrix.</dd>
<dt>eta.names</dt>
<dd>A character vector of names for each random effect
(defaults to the column names of <code>omega</code>, or if <code>NULL</code> then to
ETA1, ETA2, ...).</dd></dl>

Arguments

Generate individual random effects from a multivariate normal distribution. — generateETA

<dl>

<dt>n</dt>
<dd>The number of individuals.</dd>


<dt>omegaLT</dt>
<dd>A numeric vector giving the elements of the lower triangle
of the covariance matrix by row.</dd>


<dt>omega</dt>
<dd>The covariance matrix.</dd>


<dt>eta.names</dt>
<dd>A character vector of names for each random effect
(defaults to the column names of <code>omega</code>, or if <code>NULL</code> then to
ETA1, ETA2, ...).</dd>

</dl>

generateETA: Generate individual random effects from a multivariate normal distribution.

Description

Usage

Value

Arguments

See Also

Examples