whhl

This is metabolome data from plasma, liver, heart and brain samples of normal, hyperlipidemic, and statin-treated rabbits measured by capillary electrophoresis time-of-flight mass spectrometry. The data matrix contains 9 samples (3 samples in each groups).

 datasets

Computing statistical hypothesis testing for loading in principal component analysis (PCA) (Yamamoto, H. et al. (2014) <doi:10.1186/1471-2105-15-51>), orthogonal smoothed PCA (OS-PCA) (Yamamoto, H. et al. (2021) <doi:10.3390/metabo11030149>), one-sided kernel PCA (Yamamoto, H. (2023) <doi:10.51094/jxiv.262>), partial least squares (PLS) and PLS discriminant analysis (PLS-DA) (Yamamoto, H. et al. (2009) <doi:10.1016/j.chemolab.2009.05.006>), PLS with rank order of groups (PLS-ROG) (Yamamoto, H. (2017) <doi:10.1002/cem.2883>), regularized canonical correlation analysis discriminant analysis (RCCA-DA) (Yamamoto, H. et al. (2008) <doi:10.1016/j.bej.2007.12.009>), multiset PLS and PLS-ROG (Yamamoto, H. (2022) <doi:10.1101/2022.08.30.505949>).

Hiroyuki Yamamoto

loadings

Loadings for Principal Component Analysis and Partial Least
Squares

whhl function

The list object "whhl" contains the following elements:
X : List of data matrix that include samples in each rows and metabolites in each columns for plasma, liver, heart and brain samples.
Y : Dummy matrix that include group information 0,1 in each columns.
D : Example of differential matrix used in PLS-ROG or multiset PLS-ROG.
tau : Example of strength parameter matrix used in mutliset PLS or multiset PLS-ROG. All weights were set as the same value of 0.1.

whhl: Metabolome analysis of plasma, liver, heart and brain samples from rabbits with hyperlipidemia.

Description

Usage

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