`loewesadditivity`

The goal of loewesadditivity is to determine whether a combination of certain compounds has additivity/synergy/antagonism in terms of the measured GIA%.

Installation

You can install the released version of loewesadditivity from CRAN with:

install.packages("loewesadditivity")

Vignette

Get started with the below vignette.

library(loewesadditivity)
vignette("loewesadditivity")

Copy Link

Version

Install

install.packages('loewesadditivity')

Monthly Downloads

190

Version

0.1.0

License

MIT + file LICENSE

Maintainer

Shannon Gallagher

Last Published

March 24th, 2020

Functions in loewesadditivity (0.1.0)

make_grid

Make a grid of points

simulate_coverage

Simulate a GIA model with an assumed error structure

base_GIA

Estimate GIA according to the base model

plot_isobologram

Plot the estimated isobologram

plot_curves

Plot the surface and observations

Plot the surface and observations

fortify_gia_data

Put GIA measurements into a dplyr format

rh5_ama1ron2

RH5 and AMA1RON2

get_ed_line

Helper function to get the ED50 line

cyrpa_ripr

CyRPA and RIPR

design_grid

Function to design an experimental grid of combinations

calc_S

Calculate S generally

SSE_GIA

Calculate the Sum of Squared Error

design_experiment

Helper function to generate code to run an experiment

calc_S_base

Calculate S from given tau_1 for base model

boot_GIA

Helper function for the bootstrap results

estimate_GIA

Take in dose A and dose B combinations and estimate GIA

estimate_params

Estimate the parameters for a given data set and model