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lpNet (version 2.4.0)

lpNet-package: Network Inference Of Perturbation Data Using a Linear Programming Approach.

Description

lpNet aims at infering biological networks, in particular signaling and gene networks. For that it takes perturbation data, either steady-state or time-series, as input and generates an LP model which allows the inference of signaling networks. For parameter identification either leave-one-out cross-validation or stratified n-fold cross-validation can be used.

Arguments

Details

Package:
lpNet
Type:
Package
Version:
1.99.2
Date:
2013-01-11
License:
Artistic License 2.0

References

Bettina Knapp and Lars Kaderali, Reconstruction of cellular signal transduction networks using perturbation assays and linear programming, PLoS ONE, 2013.

Marta R. A. Matos, Network inference : extension of linear programming model for time-series data, Master's thesis, Department of Informatics, University of Minho.