- betaNew
The type II error for the secondary trial.
- INew
The maximum information of the secondary trial. Either
betaNew or INew should be provided while the other one
should be missing.
- L
The interim adaptation look of the primary trial.
- zL
The z-test statistic at the interim adaptation look of
the primary trial.
- theta
The parameter value.
- IMax
The maximum information of the primary trial. Must be
provided if futilityBounds is missing and
typeBetaSpending is not equal to "none", or
if conditional power calculation is desired.
- kMax
The maximum number of stages of the primary trial.
- informationRates
The information rates of the primary trial.
- efficacyStopping
Indicators of whether efficacy stopping is
allowed at each stage of the primary trial. Defaults to true
if left unspecified.
- futilityStopping
Indicators of whether futility stopping is
allowed at each stage of the primary trial. Defaults to true
if left unspecified.
- criticalValues
The upper boundaries on the z-test statistic scale
for efficacy stopping for the primary trial.
- alpha
The significance level of the primary trial.
Defaults to 0.025.
- typeAlphaSpending
The type of alpha spending for the primary
trial. One of the following:
"OF" for O'Brien-Fleming boundaries,
"P" for Pocock boundaries,
"WT" for Wang & Tsiatis boundaries,
"sfOF" for O'Brien-Fleming type spending function,
"sfP" for Pocock type spending function,
"sfKD" for Kim & DeMets spending function,
"sfHSD" for Hwang, Shi & DeCani spending function,
"user" for user defined spending, and
"none" for no early efficacy stopping.
Defaults to "sfOF".
- parameterAlphaSpending
The parameter value of alpha spending
for the primary trial. Corresponds to Delta for "WT", rho for "sfKD",
and gamma for "sfHSD".
- userAlphaSpending
The user defined alpha spending for the primary
trial. Cumulative alpha spent up to each stage.
- futilityBounds
The lower boundaries on the z-test statistic scale
for futility stopping for the primary trial. Defaults to
rep(-6, kMax-1) if left unspecified.
- typeBetaSpending
The type of beta spending for the primary trial.
One of the following:
"sfOF" for O'Brien-Fleming type spending function,
"sfP" for Pocock type spending function,
"sfKD" for Kim & DeMets spending function,
"sfHSD" for Hwang, Shi & DeCani spending function, and
"none" for no early futility stopping.
Defaults to "none".
- parameterBetaSpending
The parameter value of beta spending
for the primary trial. Corresponds to rho for "sfKD",
and gamma for "sfHSD".
- spendingTime
The error spending time of the primary trial.
Defaults to missing, in which case, it is the same as
informationRates.
- MullerSchafer
Whether to use the Muller and Schafer (2001) method
for trial adaptation.
- kNew
The number of looks of the secondary trial.
- informationRatesNew
The spacing of looks of the secondary trial.
- efficacyStoppingNew
The indicators of whether efficacy stopping is
allowed at each look of the secondary trial. Defaults to true
if left unspecified.
- futilityStoppingNew
The indicators of whether futility stopping is
allowed at each look of the secondary trial. Defaults to true
if left unspecified.
- typeAlphaSpendingNew
The type of alpha spending for the secondary
trial. One of the following:
"OF" for O'Brien-Fleming boundaries,
"P" for Pocock boundaries,
"WT" for Wang & Tsiatis boundaries,
"sfOF" for O'Brien-Fleming type spending function,
"sfP" for Pocock type spending function,
"sfKD" for Kim & DeMets spending function,
"sfHSD" for Hwang, Shi & DeCani spending function, and
"none" for no early efficacy stopping.
Defaults to "sfOF".
- parameterAlphaSpendingNew
The parameter value of alpha spending
for the secondary trial. Corresponds to Delta for "WT", rho for "sfKD",
and gamma for "sfHSD".
- typeBetaSpendingNew
The type of beta spending for the secondary
trial. One of the following:
"sfOF" for O'Brien-Fleming type spending function,
"sfP" for Pocock type spending function,
"sfKD" for Kim & DeMets spending function,
"sfHSD" for Hwang, Shi & DeCani spending function,
"user" for user defined spending, and
"none" for no early futility stopping.
Defaults to "none".
- parameterBetaSpendingNew
The parameter value of beta spending
for the secondary trial. Corresponds to rho for "sfKD",
and gamma for "sfHSD".
- userBetaSpendingNew
The user defined cumulative beta spending.
Cumulative beta spent up to each stage of the secondary trial.
- spendingTimeNew
The error spending time of the secondary trial.
Defaults to missing, in which case, it is the same as
informationRatesNew.
- varianceRatio
The ratio of the variance under H0 to the
variance under H1.