transMatMSM

Define transition matrices for multi-state model. Specific
functions for defining such transition matrices are pre-defined for common
multi-state models like the competing risks model and the illness-death model.

The inference in multi-state models is traditionally performed under
a Markov assumption that claims that past and future of the process
are independent given the present state. In this package, we
consider tests of the Markov assumption that are applicable to
general multi-state models. Three approaches using existing
methodology are considered: a simple method based on including
covariates depending on the history in Cox models for the transition
intensities; methods based on measuring the discrepancy of the
non-Markov estimators of the transition probabilities to the
Markov Aalen-Johansen estimators; and, finally, methods that were
developed by considering summaries from families of log-rank
statistics where patients are grouped by the state occupied of the
process at a particular time point (see Soutinho G, Meira-Machado L
(2021) <doi:10.1007/s00180-021-01139-7> and Titman AC, Putter H
(2020) <doi:10.1093/biostatistics/kxaa030>).

Gustavo Soutinho

markovMSM

Methods for Checking the Markov Condition in Multi-State
Survival Data

Luis Meira-Machado

transMatMSM function

<dl><dt>positions</dt>
<dd>List of possible transitions; x[[i]] consists of a vector of
state numbers reachable from state i.</dd>
<dt>namesStates</dt>
<dd>A character vector containing the names of either the
competing risks or the states in the multi-state model specified by the
competing risks or illness-death model. names should have the same 
length as the list x (for transMat), or either K or K+1 (for trans.comprisk),
or 3 (for trans.illdeath).</dd></dl>

Arguments

Gustavo Soutinho and Luis Meira-Machado.

Author

Define transition matrix for multi-state model. — transMatMSM

<dl>

<dt>positions</dt>
<dd>List of possible transitions; x[[i]] consists of a vector of
state numbers reachable from state i.</dd>


<dt>namesStates</dt>
<dd>A character vector containing the names of either the
competing risks or the states in the multi-state model specified by the
competing risks or illness-death model. names should have the same 
length as the list x (for transMat), or either K or K+1 (for trans.comprisk),
or 3 (for trans.illdeath).</dd>

</dl>

transMatMSM: Define transition matrix for multi-state model.

Description

Usage

Value

Arguments

Author

Examples