This package contains functions for comparing survival curves using the max-combo test at a single timepoint or repeatedly at successive respective timepoints while controlling type I error (i.e., the group sequential setting), as published by Tom Prior (Prior 2020 Group sequential monitoring based on the maximum of weighted log-rank statistics with the Fleming-Harrington class of weights in oncology clinical trials). The max-combo test is a generalization of the weighted log-rank test, which itself is a generalization of the log-rank test, which is a commonly used statistical test for comparing survival curves, e.g., during or after a clinical trial as part of an effort to determine if a new drug or therapy is more effective at delaying undesirable outcomes than an established drug or therapy or a placebo.
This package contains the following four functions:
A reasonable way to get started with using this package is to read the documentation for those functions in the order they are listed above.
Prior 2020 Group sequential monitoring based on the maximum of weighted log-rank statistics with the Fleming-Harrington class of weights in oncology clinical trials.
(Available at: https://doi.org/10.1177/0962280220931560)