maxstat (version 0.7-1)

sphase: S-phase fraction of tumor cells

Description

S-phase fraction of tumor cells in breast cancer patients.

Usage

data(sphase)

source

J. Pfisterer, F. Kommoss, W. Sauerbrei, D. Menzel, M. Kiechle, E. Giese, M. Hilgarth & A. Pfleiderer (1995). DNA flow cytometry in node positive breast cancer: Prognostic value and correlation to morphological and clinical factors. Analytical and Quantitative Cytology and Histology 7(6), 406--412.

Details

The data have been used to address the question whether a simple cutpoint in S-phase fraction can be used to discriminate between patients with good and bad prognosis (for example in Hothorn & Lausen, 2003).

References

Torsten Hothorn & Berthold Lausen (2003). On the Exact Distribution of Maximally Selected Rank Statistics. Computational Statistics & Data Analysis 43, 121--137.

Examples

data(sphase)
maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank",
pmethod="Lau94")
maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank",
pmethod="Lau94", iscores=TRUE)
maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank",
pmethod="HL")
maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank",
pmethod="condMC", B = 9999)
plot(maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank"))