maxstat (version 0.7-16)

sphase: S-phase fraction of tumor cells

Description

S-phase fraction of tumor cells in breast cancer patients.

Usage

data("sphase")

source

J. Pfisterer, F. Kommoss, W. Sauerbrei, D. Menzel, M. Kiechle, E. Giese, M. Hilgarth & A. Pfleiderer (1995). DNA flow cytometry in node positive breast cancer: Prognostic value and correlation to morphological and clinical factors. Analytical and Quantitative Cytology and Histology 7(6), 406--412.

Details

The data have been used to address the question whether a simple cutpoint in S-phase fraction can be used to discriminate between patients with good and bad prognosis (for example in Hothorn & Lausen, 2003).

References

Torsten Hothorn & Berthold Lausen (2003). On the Exact Distribution of Maximally Selected Rank Statistics. Computational Statistics & Data Analysis 43, 121--137.

Examples

set.seed(29)

maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank",
             pmethod="Lau94")

maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank",
             pmethod="Lau94", iscores=TRUE)

maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank",
             pmethod="HL")

maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank",
             pmethod="condMC", B = 9999)

plot(maxstat.test(Surv(RFS, cens) ~ SPF, data=sphase, smethod="LogRank"))