FastKerFdr

Computes H1 posteriors of the Z-scores.

Provides functions to perform all steps of genome-wide
association meta-analysis for studying Genotype x Environment
interactions, from collecting the data to the manhattan plot.  The
procedure accounts for the potential correlation between studies. In
addition to the Fixed and Random models, one can investigate the
relationship between QTL effects and some qualitative or quantitative
covariate via the test of contrast and the meta-regression,
respectively.  The methodology is available from: (De Walsche, A., et
al. (2025) \doi{10.1371/journal.pgen.1011553}).

Annaïg De Walsche

metaGE

Meta-Analysis for Detecting Genotype x Environment Associations

Tristan Mary-Huard

FastKerFdr function

<dl><dt>Z</dt>
<dd>A vector containing Zscores</dd>
<dt>p0</dt>
<dd>A double between 0 and 1. A priori proportion of H0 hypotheses</dd>
<dt>plotting</dt>
<dd>A boolean saying to plot or not (FALSE by default)</dd>
<dt>NbKnot</dt>
<dd>The (maximum) number of knot for the kde procedure.(1e5 by default)</dd>
<dt>tol</dt>
<dd>a tolerance value for convergence (1e-5 by default)</dd>
<dt>max_iter</dt>
<dd>the maximum number of iterations allowed for the algorithm to converge or complete its process.(Default is 1e4.)</dd></dl>

Arguments

FastKerFdr — FastKerFdr

<dl>

<dt>Z</dt>
<dd>A vector containing Zscores</dd>


<dt>p0</dt>
<dd>A double between 0 and 1. A priori proportion of H0 hypotheses</dd>


<dt>plotting</dt>
<dd>A boolean saying to plot or not (FALSE by default)</dd>


<dt>NbKnot</dt>
<dd>The (maximum) number of knot for the kde procedure.(1e5 by default)</dd>


<dt>tol</dt>
<dd>a tolerance value for convergence (1e-5 by default)</dd>


<dt>max_iter</dt>
<dd>the maximum number of iterations allowed for the algorithm to converge or complete its process.(Default is 1e4.)</dd>

</dl>

FastKerFdr: FastKerFdr

Description

Usage

Value

Arguments