metaMA (version 1.2)

directpvalcombi: Direct p-value combination

Description

Combines one sided p-values with the inverse normal method.

Usage

directpvalcombi(pvalonesided, nrep, BHth = 0.05)

Arguments

pvalonesided

List of vectors of one sided p-values to be combined.

nrep

Vector of numbers of replicates used in each study to calculate the previous one-sided p-values.

BHth

Benjamini Hochberg threshold. By default, the False Discovery Rate is controlled at 5%.

Value

• List
• DEindices
  Indices of differentially expressed genes at the chosen Benjamini Hochberg threshold.
• TestStatistic
  Vector with test statistics for differential expression in the meta-analysis.

References

Hedges, L. and Olkin, I. (1985). Statistical Methods for Meta-Analysis. Academic Press.