metadat (version 1.4-0)

dat.cannon2006: Studies on the Effectiveness of Intensive Versus Moderate Statin Therapy for Preventing Coronary Death or Myocardial Infarction

Description

Results from 4 trials examining the effectiveness of intensive (high dose) versus moderate (standard dose) statin therapy for preventing coronary death or myocardial infarction.

Usage

dat.cannon2006

Format

The data frame contains the following columns:

trial	character	trial name
pop	character	study population (post-ACS: post acute coronary syndrome; stable CAD: stable coronary artery disease)
nt	numeric	number of patients in the high dose group
nc	numeric	number of patients in the standard dose group
ep1t	numeric	number of events in the high dose group for end point 1: coronary death or non-fatal myocardial infarction
ep1c	numeric	number of events in the standard dose group for end point 1: coronary death or non-fatal myocardial infarction
ep2t	numeric	number of events in the high dose group for end point 2: coronary death or any cardiovascular event (MI, stroke, hospitalization for unstable angina, or revascularization)
ep2c	numeric	number of events in the standard dose group for end point 2: coronary death or any cardiovascular event (MI, stroke, hospitalization for unstable angina, or revascularization)
ep3t	numeric	number of events in the high dose group for end point 3: cardiovascular death
ep3c	numeric	number of events in the standard dose group for end point 3: cardiovascular death
ep4t	numeric	number of events in the high dose group for end point 4: non-cardiovascular death
ep4c	numeric	number of events in the standard dose group for end point 4: non-cardiovascular death
ep5t	numeric	number of events in the high dose group for end point 5: deaths (all-cause mortality)
ep5c	numeric	number of events in the standard dose group for end point 5: deaths (all-cause mortality)
ep6t	numeric	number of events in the high dose group for end point 6: stroke
ep6c	numeric	number of events in the standard dose group for end point 6: stroke

Author

Wolfgang Viechtbauer, , https://www.metafor-project.org

Concepts

medicine, cardiology, odds ratios, Mantel-Haenszel method

Details

The data were obtained from Figures 2, 3, 4, and 5 in Cannon et al. (2006). The authors used the Mantel-Haenszel method for combining the results from the 4 trials. This approach is implemented in the rma.mh function.

Examples

### copy data into 'dat' and examine data
dat <- dat.cannon2006
dat

if (FALSE) {
### load metafor package
library(metafor)

### meta-analysis of log odds ratios using the MH method for endpoint 1
res <- rma.mh(measure="OR", ai=ep1t, n1i=nt, ci=ep1c, n2i=nc, data=dat, slab=trial)
print(res, digits=2)

### forest plot
forest(res, xlim=c(-.8,0.8), atransf=exp, at=log(c(2/3, 1, 3/2)),
       cex=1.2, xlab="Odds Ratio")
mtext("(high dose better)", side=1, line=par("mgp")[1]-0.5, at=log(2/3), cex=1.2, font=3)
mtext("(standard dose better)", side=1, line=par("mgp")[1]-0.5, at=log(3/2), cex=1.2, font=3)
}