metadat (version 1.4-0)

dat.ursino2021: Sorafenib Toxicity Dataset

Description

13 studies investigating the occurrence of dose limiting toxicities (DLTs) at different doses of Sorafenib.

Usage

dat.ursino2021

Format

The data frame contains the following columns:

study	character	study label
year	integer	publication year
dose	numeric	dose (\(\mathrm{mg}\))
events	integer	number of DLTs
total	integer	number of patients exposed

Author

Christian Roever,

Concepts

medicine, oncology, dose-response models

Details

Sorafenib (BAY 43-9006, Nexavar) is a kinase inhibitor that is used in the treatment of advanced renal cell carcinoma, hepatocellular carcinoma, and radioactive iodine resistant advanced thyroid carcinoma. Thirteen trials with published results, described in eleven manuscripts, were identified in a literature search. This dataset contains the doses investigated, the numbers of patients treated, and the number of dose-limiting toxicities (DLTs) observed. In general, each study investigated several doses according to some dose-escalation scheme.

References

European Medicines Agency (EMA) (2022). Nexavar (sorafenib) EPAR summary. https://www.ema.europa.eu/en/medicines/human/EPAR/nexavar

Awada, A., Hendlisz, A., Gil, T., et al. (2005). Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on / 7 days off in patients with advanced, refractory solid tumours. British Journal of Cancer, 92(10), 1855. https://doi.org/10.1038/sj.bjc.6602584

Clark, J. W., Eder, J. P., Ryan, D., Lathia, C., & Lenz, H.-J. (2005). Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors. Clinical Cancer Research, 11(15), 5472--5480. https://doi.org/10.1158/1078-0432.CCR-04-2658

Moore, M., Hirte, H. W., Siu, L., et al. (2005). Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on / 7 days off in patients with advanced, refractory solid tumors. Annals of Oncology, 16(10), 1688--1694. https://doi.org/10.1093/annonc/mdi310

Strumberg, D., Richly, H., Hilger, R. A., et al. (2005). Phase I clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. Journal of Clinical Oncology, 23(5), 965--972. https://doi.org/10.1200/JCO.2005.06.124

Furuse, J., Ishii, H., Nakachi, K., Suzuki, E., Shimizu, S., & Nakajima, K. (2008). Phase I study of sorafenib in Japanese patients with hepatocellular carcinoma. Cancer Science, 99(1), 159--165. https://doi.org/10.1111/j.1349-7006.2007.00648.x

Minami, H., Kawada, K., Ebi, H., et al. (2008). Phase I and pharmacokinetic study of sorafenib, an oral multikinase inhibitor, in Japanese patients with advanced refractory solid tumors. Cancer Science, 99(7), 1492--1498. https://doi.org/10.1111/j.1349-7006.2008.00837.x

Miller, A. A., Murry, D. J., Owzar, K., et al. (2009). Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301. Journal of Clinical Oncology, 27(11), 1800. https://doi.org/10.1200/JCO.2008.20.0931

Crump, M., Hedley, D., Kamel-Reid, S., et al. (2010). A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: A NCIC (National Cancer Institute of Canada) Clinical Trials Group Study. Leukemia and Lymphoma, 51(2), 252--260. https://doi.org/10.3109/10428190903585286

Borthakur, G., Kantarjian, H., Ravandi, F., et al. (2011). Phase I study of sorafenib in patients with refractory or relapsed acute Leukemias. Haematologica, 96(1), 62--68. https://doi.org/10.3324/haematol.2010.030452

Nabors, L. B., Supko, J. G., Rosenfeld, M., et al. (2011). Phase I trial of sorafenib in patients with recurrent or progressive malignant glioma. Neuro-Oncology, 13(12), 1324--1330. https://doi.org/10.1093/neuonc/nor145

Chen, Y.-B., Li, S., Lane, A. A., et al. (2014). Phase I trial of maintenance sorafenib after allogeneic hematopoietic stem cell transplantation for FMS-like tyrosine kinase 3 internal tandem duplication acute myeloid leukemia. Biology of Blood and Marrow Transplantation, 20(12), 2042--2048. https://doi.org/10.1016/j.bbmt.2014.09.007

See Also

dat.roever2022

Examples

# show (some) data
head(dat.ursino2021, n=15)

if (FALSE) {
# illustrate data
plot(NA, xlim=range(dat.ursino2021$dose), ylim=0:1,
     xlab="dose (mg)", ylab="proportion",
     main="dat.ursino2021 (Sorafenib data)")
studylab <- unique(dat.ursino2021$study)
colvec <- rainbow(length(studylab))
for (i in 1:length(studylab)) {
  idx <- (dat.ursino2021$study == studylab[i])
  lines(dat.ursino2021[idx,"dose"],
        dat.ursino2021[idx,"events"] / dat.ursino2021[idx,"total"],
        col=colvec[i], type="b")
}
legend("topleft", studylab, col=colvec, pch=15)
}