Failure time data for 64 patients having severe aplastic anemia. Patients were randomly assigned to receive either cyclosporine plus methotrexate (CSPMTX) or methotrexate alone (MTX) with time from assignment to the diagnosis of stage 2 or greater acute graft versus host disease (A-GVHD) as a key outcome.
data(anemia)A data frame with 64 rows and 5 variables:
Treatment group, either cyclosporine and methotrexate (CSPMTX) or methotrexate only (MTX).
Time in days to severe (stage >=2) acute graft versus host disease, death, or last contact.
Patient assigned to laminar air flow isolation room at baseline. LAF = 1 signifies yes, LAF = 0 signifies no.
Age of patient in years.
Boolean for whether or not time to severe A-GVHD is right-censored; i.e., the patient died without severe A-GVHD or was without severe A-GVHD at last contact.
Prentice, R., Zhao, S. "The statistical analysis of multivariate failure time data: A marginal modeling approach", CRC Press (2019).