miRada (version 1.13.8-8)

OX40Exiqon: A sample data of Exiqon microRNA microarray

Description

A sample microRNA expression profiling data using miRCURY LNA microRNA Array based on miRbase 9.2 (Exiqon Inc., Denmark) for 40 human osteosarcoma xenograft specimens, including 10 samples for each chemotherapeutic treatment (Cisplatin, Doxorubicin, and Ifosfamide) plus 10 non-treated samples.

Usage

data(OX40Exiqon)

Format

A data frame with 168192 rows and 7 columns (variables).

Gene	character
MicroRNA names.	Flag
numeric	an indictor showing the probe signal quality.
Repeat	numeric
an indictor showing the technical replicates.	Treat
numeric	treatment type: coded.
Sample	numeric
sample id.	Signal
numeric	fluorescence intensity measures
Background	numeric
measures of background noises	Gene

References

Wang, B., Zhang, S-G., Wang, X-F., Tan, M. and Xi, Y. (2012) "Testing for differentially-expressed microRNAs with errors-in-variables nonparametric regression", PLoS ONE 7(5): e37537. doi:10.1371/journal.pone.0037537.

Wang, B., Wang, X-F. and Xi, Y. (2011) "Normalizing bead-based microRNA expression data: a measurement error model-based approach", Bioinformatics, 27(11), 1506-1512.

Wang, B., Howell, P., Bruheim, S. Ju, J, Owen, L.B., Fodstad, O. and Xi, Y. (2011). "Systematic Evaluation of Three microRNA Profiling Platforms: Microarray, Beads Array, and Quantitative Real-Time PCR Array", PLoS ONE 6(2): e17167.

Wang, B. and Wertelecki, W. (2012) "Density Estimation for Data With Rounding Errors", Computational Statistics and Data Analysis, (in press). doi: 10.1016/j.csda.2012.02.016. link

Wang, B., Wang, X-F. and Xi, Y. (2011) "Normalizing bead-based microRNA expression data: a measurement error model-based approach", Bioinformatics, 27(11), 1506-1512.

Wang, X-F. and Wang, B. (2011) "Deconvolution Estimation in Measurement Error Models: The R Package decon", Journal of Statistical Software, 39(10), 1-24.

Examples

 data(OX40Exiqon)
 ex = structure(list(x = ox40ex92), class='exiqon')
 print(ex)