micronutr (version 0.1.1)

detect_inflammation: Determine inflammation status

Description

Given laboratory values for serum c-reactive protein (CRP) and/or serum alpha(1)-acid-glycoprotein (AGP), the inflammation status of a subject can be determined based on cut-off values described in Namaste, S. M., Rohner, F., Huang, J., Bhushan, N. L., Flores-Ayala, R., Kupka, R., Mei, Z., Rawat, R., Williams, A. M., Raiten, D. J., Northrop-Clewes, C. A., & Suchdev, P. S. (2017). Adjusting ferritin concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. The American journal of clinical nutrition, 106(Suppl 1), 359S–371S. https://doi.org/10.3945/ajcn.116.141762

Usage

detect_inflammation(crp = NULL, agp = NULL, label = TRUE)
detect_inflammation_crp(crp = NULL, label = TRUE)
detect_inflammation_agp(agp = NULL, label = TRUE)

Value

If label is TRUE, a character value or character vector of inflammation classification based on c-reactive protein (CRP) and/or alpha(1)-acid-glycoprotein (AGP) values. If label is FALSE, an integer value or vector of inflammation classification.

Arguments

crp

A numeric value or numeric vector of c-reactive protein (crp) values in micrograms per litre (microgram/l).

agp

A numeric value or numeric vector of alpha(1)-acid-glycoprotein (agp) values in micrograms per litre (microgram/l).

label

Logical. Should labels be used to classify inflammation status? If TRUE (default), status is classified as "no inflammation" or "inflammation" based on either CRP or AGP or status is classified as "no inflammation", "incubation", "early convalescence", or "late convalescence" based on both CRP and AGP. If FALSE, simple integer codes are returned: 0 for no inflammation and 1 for inflammation based on either CRP or AGP; 0 for no inflammation, 1 for incubation, 2 for early convalescence, or 3 for late convalescence.

Author

Nicholus Tint Zaw and Ernest Guevarra

Examples

## Detect inflammation by AGP
detect_inflammation_agp(2)
detect_inflammation_agp(2, label = FALSE)

## Detect inflammation by CRP
detect_inflammation_crp(2)
detect_inflammation(crp = mnData$crp)
detect_inflammation(crp = mnData$crp, label = FALSE)

## Detect inflammation by AGP and CRP
detect_inflammation(crp = 2, agp = 2)
detect_inflammation(crp = 2, agp = 2, label = FALSE)