PBCseq: Mayo Clinic Primary Biliary Cirrhosis, sequential data

Description

This data is a continuation of the PBC data set (pbc), and contains the follow-up laboratory data for each study patient. An analysis based on the data can be found in Murtagh et al. (1994). The primary PBC data set contains only baseline measurements of the laboratory paramters. This data set contains multiple laboratory results, but only on the 312 randomized patients. Some baseline data values in this file differ from the original PBC file, for instance, the data errors in prothrombin time and age which were discovered after the orignal analysis (see Fleming and Harrington, 1991, figure 4.6.7).

Usage

data(PBCseq)

Arguments

Format

a data frame with 1 945 rows and the following variables

id: identification number of a patient
sex: 0/1 for male and female
fsex: factor of above
drug: 0/1 for placebo and D-penicillamine
fdrug: factor of above
age: age at entry in years
fu.days: total number of follow up days
alive: number of days when the patient is known to be alive and without liver transplantation
status: status at endpoint, 0/1/2 for censored, liver transplant, dead
fstatus: factor of above
delta.death: 0/1 censoring indicator for event = death (i.e., liver transplantation means censoring)
delta.ltx.death: 0/1 censoring indicator for event = death or liver transplantation
day: number of days between enrollment and this visit date (all measurements below refer to this date)
month: number of months between enrollment and this visit date
ascites: 0/1 presence of ascites
fascites: factor of above
hepatom: 0/1 presence of hepatomegaly or enlarged liver
fhepatom: factor of above
spiders: 0/1 presence of blood vessel malformations in the skin
fspiders: factor of above
edema: presence and status of edema, 0 for no edema, 0.5 for untreated or successfully treated edema, 1 for edema despite diuretic therapy
fedema: factor of above
stage: histologic stage of disease (needs biopsy)
fstage: factor of above
bili: serum bilirubin (mg/dl)
lbili: natural logarithm of above
albumin: serum albumin (mg/dl)
lalbumin: natural logarithm of above
alk.phos: alkaline phosphotase (U/liter)
lalk.phos: natural logarithm of above
chol: serum cholesterol (mg/dl)
lchol: natural logarithm of above
sgot: serum glutamic-oxaloacetic transaminase (the enzyme name has subsequently changed to “ALT” in the medical literature) (U/ml)
lsgot: natural logarithm of above
platelet: platelet count
lplatelet: natural logarithm of above
protime: standardised blood clotting time
lprotime: natural logarithm of above

Source

URL: http://lib.stat.cmu.edu/datasets/

References

Dickson, E. R., Grambsch, P. M., Fleming, T. R., Fisher, L. D., and Langworthy, A. (1989). Prognosis in primary biliary-cirrhosis -- Model for decision-making. Hepatology, 10, 1--7.

Fleming, T. R. and Harrington, D. P. (1991). Counting Processes and Survival Analysis. New York: John Wiley and Sons.

Markus, B. H., Dickson, E. R., Grambsch, P. M., Fleming, T. R., Mazzaferro, V., Klintmalm, G. B. G., Wiesner, R. H., Vanthiel, D. H., and Starzl, T. E. (1989). Efficacy of liver-transplantation in patients with primary biliary-cirrhosis. New England Journal of Medicine, 320, 1709--1713.

Murtaugh, P. A., Dickson, E. R., Van Dam, G. M., Malinchoc, M., Grambsch, P. M., Langworthy, A. L., and Gips, C. H. (1994). Primary biliary cirrhosis: Prediction of short-term survival based on repeated patient visits. Hepatology, 20, 126-134.

Therneau, T. M. and Grambsch, P. M. (2000). Modeling Survival Data: Extending the Cox Model. New York: Springer-Verlag.

Examples

Run this code

data(PBCseq)
summary(PBCseq)

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