cytotox: Cytotoxicity of Heavy Metals and Ionic Liquids on MCF-7
Description
Chemicals include four heavy metals:
${\rm{NiN}}{{\rm{O}}_{\rm{3}}}\cdot 6{{\rm{H}}_{\rm{2}}}{\rm{O}}$(Ni),
${\rm{ZnS}}{{\rm{O}}_{\rm{4}}} \cdot {\rm{7}}{{\rm{H}}_{\rm{2}}}{\rm{O}}$ (Zn),
${\rm{CuS}}{{\rm{O}}_{\rm{4}}} \cdot 5{{\rm{H}}_{\rm{2}}}{\rm{O}}$ (Cu), and
${\rm{MnC}}{{\rm{l}}_{\rm{2}}} \cdot 4{{\rm{H}}_{\rm{2}}}{\rm{O}}$ (Mn);
four ionic liquids are 1-Octyl-3-methylimidazolium chloride (Omim),
1-Dodecyl-3-methylimidazolium chloride (Dmim), 1-Ethyl-3-methylimidazolium tetrafluoroborate
(Emim), and 1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim).
The concentration-response data include the cytotoxicity of these eight compounds
and ten mixtures designed by udcr.
The fitting information of eight chemicals and 10 udcr mixtures.
Usage
data(cytotox)
Arguments
source
The cytotoxicity experiments were conducted in our lab
Details
The monotonic concentration-response data need to be scaled into [0, 1] to suit some equaitons(
e.g., Weibull and Logit) using the following equation:
$$E = \frac{{{I_0} - {I_i}}}{{{I_0}}}$$
where $I_0$ is the average of controls for inhibition test or the average
of the maximum effect for the stimulation test and $I_i$ the average
effect of the $i^{th}$ treatment.