mixtox (version 1.2)

hormesis: Non-monotonic concentration-response data

Description

Two ionic liquids: 1-Octyl-3-methylimidazolium chloride (Omim) and 1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim). Two organic solvents: Acetonitrile(ACN) and acetone. The concentration-response data include these four compounds on firefly luciferase. The fitting information of those datasets using non-monotonic equations.

Usage

data(hormesis)

source

Eexperiments were conducted in our lab. Detailed descripttion can be found in references

Details

The non-monotonic concentration-response data need to be scaled into [0, 1] using the following equation: $$E = \frac{{{I_0} - {I_i}}}{{{I_0}}}$$ where $I_0$ is the average of controls for inhibition test or the average of the maximum effect for the stimulation test and $I_i$ the average effect of the $i^{th}$ treatment.

References

Zhu X-W, et.al. 2013. Modeling non-monotonic dose-response relationships: Model evaluation and hormetic quantities exploration. Ecotoxicol. Environ. Saf. 89:130-136.

Examples

#example 1
## Retrive the toxicity data of acetonitrile on firefly luciferase.
ACN <- hormesis$ACN

#example 2
## Retrive the minx of OmimCl, HmimCl, ACN, and Acetone
minx <- hormesis$sgl$minx