cytotox: Cytotoxicity of Heavy Metal Ions and Ionic Liquids on MCF-7
Description
Chemicals include four heavy metal ions:
${\rm{NiN}}{{\rm{O}}_{\rm{3}}}\cdot 6{{\rm{H}}_{\rm{2}}}{\rm{O}}$(Ni),
${\rm{ZnS}}{{\rm{O}}_{\rm{4}}} \cdot {\rm{7}}{{\rm{H}}_{\rm{2}}}{\rm{O}}$ (Zn),
${\rm{CuS}}{{\rm{O}}_{\rm{4}}} \cdot 5{{\rm{H}}_{\rm{2}}}{\rm{O}}$ (Cu), and
${\rm{MnC}}{{\rm{l}}_{\rm{2}}} \cdot 4{{\rm{H}}_{\rm{2}}}{\rm{O}}$ (Mn);
four ionic liquids are 1-Octyl-3-methylimidazolium chloride (Omim),
1-Dodecyl-3-methylimidazolium chloride (Dmim), 1-Ethyl-3-methylimidazolium tetrafluoroborate
(Emim), and 1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim).
The concentration-response data include the cytotoxicity of eight compounds,
two mixtures designed by eecr, and ten mixtures designed by udcr.
The fitting information of eight chemicals and a total of 12 mixtures.
Usage
data(cytotox)
Arguments
source
The cytotoxicity experiments were conducted in our lab
Details
Quantal responses[0, 1] are needed for curve fitting using the following six equaitons:
i.e., Weibull, Logit, Hill, BCL, GL, BCW. The following equation could transform
continous responses to quantal ones:
$$E = \frac{{{I_0} - {I_i}}}{{{I_0}}}$$
where $I_0$ is the average of controls for inhibition tests or the average
of the maximum effect for stimulation tests and $I_i$ the average
effect of the $i^{th}$ treatment.
# example 1## Retrive the toxicity data of Ni on MCF-7.cytotox$Ni
# example 2## Retrive the toxicity information of ten udcr mixtures on MCF-7.cytotox$udcr.mix