hormesis: Non-monotonic Concentration-response Data
Description
Two ionic liquids: 1-Octyl-3-methylimidazolium chloride (Omim) and
1-Hexyl-3-Methylimidazolium tetrafluoroborate (Hmim).
Two organic solvents: Acetonitrile(ACN) and acetone.
The concentration-response data include the effect of these four compounds
on firefly luciferase.
Those concentration-responses were fitted using non-monotonic models.
Usage
data(hormesis)
Arguments
source
Eexperiments were conducted in our lab. Detailed descripttion can be found in references
Details
The non-monotonic concentration-responses need to be scaled into [0, 1] using the
following equation:
$$E = \frac{{{I_0} - {I_i}}}{{{I_0}}}$$
where $I_0$ is the average of controls for inhibition test or the average
of the maximum effect for the stimulation test and $I_i$ the average
effect of the $i^{th}$ treatment.
References
Zhu X-W, et.al. 2013. Modeling non-monotonic dose-response relationships: Model evaluation
and hormetic quantities exploration. Ecotoxicol. Environ. Saf. 89:130-136.
#example 1## Retrive the toxicity data of acetonitrile on firefly luciferase.hormesis$ACN
#example 2## Retrive the minx of OmimCl, HmimCl, ACN, and Acetonehormesis$sgl$minx