mixtox:
Curve Fitting and Mixture Toxicity Assessment
Description
Curve Fitting for monotonic(sigmoidal) & non-monotonic(J-shaped)
concentration-response data. Prediction of mixture toxicity based on reference
models such as 'concentration addition', 'independent action', and generalized
concentration addition.
Details
|
Package: |
| mixtox |
|
Type: |
| Package |
|
Version: |
| 1.3 |
|
Date: |
| 2016-05-08 |
|
License: |
| GPL-2 |
(1) Curve fitting of concentration-responses based on 13 monotonic(sigmoidal) and 4
non-monotonic(J-shaped) models, goodness of fit, and confidence intervals
calculation.
(2) Experimental design for mixture toxicity.
acr: arbitrary concentration ratio;
eecr: equal effect concentration ratio;
udcr: uniform design concentration ratio.
(3) Mixture toxicity prediction based on reference models such as concentration addition (CA),
independent action (IA), and generalized concentration addition (GCA).
References
Dunnett, C. W. 1964. New Tables for Multiple Comparisons with a Control. Biometrics
30(3):482-491.
Hickernell, Fred J. 1996. A Generalized Discrepancy and Quadrature Error Bound. Mathematics of
Computation 67(211):299-322.
Howard, Gregory J., Jennifer J. Schlezinger, Mark E. Hahn, and Thomas F. Webster. 2010.
Generalized Concentration Addition Predicts Joint Effects of Aryl Hydrocarbon
Receptor Agonists with Partial Agonists and Competitive Antagonists.
Environmental Health Perspectives 118(5):666-672.
Scholze, M. et al. 2001. A General Best-Fit Method for Concentration-Response Curves and the
Estimation of Low-Effect Concentrations. Environmental Toxicology and Chemistry
20(2):448-457.
Wang, Yuan and Kai-Tai Fang. 1996. Uniform Design of Experiments with Mixtures. Science in China
Series A-Mathematics Physics Astronomy 39(3):264-275.
Backhaus, T., Faust, M., 2012. Predictive environmental risk assessment of chemical mixtures: A
conceptual framework. Environmental Science and Technology. 46, 2564-2573.
Zhu X-W, Liu S-S, Qin L-T, Chen F, Liu H-L. 2013. Modeling non-monotonic dose-response
relationships: Model evaluation and hormetic quantities exploration. Ecotoxicology and
Environmental Safety 89:130-136.
Di Veroli GY, Fornari C, Goldlust I, Mills G, Koh SB, Bramhall JL, et al. 2015. An automated
fitting procedure and software for dose-response curves with multiphasic features.
Scitific Report 5: 14701.