h_assert_lrt_suitability

Throws an error if the degrees of freedom aren't monotonically increasing, if
the models aren't nested, or if <code>refit = FALSE</code> and the models have different
underlying data.

internal

Mixed models for repeated measures (MMRM) are a popular
choice for analyzing longitudinal continuous outcomes in randomized
clinical trials and beyond; see Cnaan, Laird and Slasor (1997)
<doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E>
for a tutorial and Mallinckrodt, Lane, Schnell, Peng and Mancuso
(2008) <doi:10.1177/009286150804200402> for a review. This package
implements MMRM based on the marginal linear model without random
effects using Template Model Builder ('TMB') which enables fast and
robust model fitting. Users can specify a variety of covariance
matrices, weight observations, fit models with restricted or standard
maximum likelihood inference, perform hypothesis testing with
Satterthwaite or Kenward-Roger adjustment, and extract least square
means estimates by using 'emmeans'.

Daniel Sabanes Bove

mmrm

Mixed Models for Repeated Measures

Liming Li

Julia Dedic

Doug Kelkhoff

Kevin Kunzmann

Brian Matthew Lang

Christian Stock

Ya Wang

Craig Gower-Page

Dan James

Jonathan Sidi

Daniel Leibovitz

Daniel D. Sjoberg

Nikolas Ivan Krieger

Lukas A. Widmer

Boehringer Ingelheim Ltd. 

Gilead Sciences, Inc. 

F. Hoffmann-La Roche AG 

Merck Sharp & Dohme, Inc. 

AstraZeneca plc 

inferential.biostatistics GmbH 

h_assert_lrt_suitability function

<dl><dt>fits</dt>
<dd>(<code>list</code>) list of <code>mmrm</code> fits.</dd>
<dt>refit</dt>
<dd>(<code>flag</code>) <code>TRUE</code> or <code>FALSE</code> indicating whether or not the user
gave permission to refit models to make all models suitable for LRT.</dd>
<dt>dfs</dt>
<dd>(<code>numeric</code>) vector of the degrees of freedom for each element
of <code>fits</code>.</dd>
<dt>is_reml</dt>
<dd>(<code>logical</code>) vector indicating whether or not REML was used
for each element of <code>fits</code>.</dd></dl>

Arguments

Ensure LRT Is Appropriate for list of mmrm Fits — h_assert_lrt_suitability

<dl>

<dt>fits</dt>
<dd>(<code>list</code>) list of <code>mmrm</code> fits.</dd>


<dt>refit</dt>
<dd>(<code>flag</code>) <code>TRUE</code> or <code>FALSE</code> indicating whether or not the user
gave permission to refit models to make all models suitable for LRT.</dd>


<dt>dfs</dt>
<dd>(<code>numeric</code>) vector of the degrees of freedom for each element
of <code>fits</code>.</dd>


<dt>is_reml</dt>
<dd>(<code>logical</code>) vector indicating whether or not REML was used
for each element of <code>fits</code>.</dd>

</dl>

Ensure LRT Is Appropriate for <code>list</code> of <code>mmrm</code> Fits

h_assert_lrt_suitability: Ensure LRT Is Appropriate for `list` of `mmrm` Fits

Description

Usage

Value

Arguments