sample_size

matrix of measurement data used for correlation computation

string indicating handling of missing data. Can be 'all.obs' for all observations
or 'pairwise.complete.obs' for pairwise observations

(INTERNAL) Depending on how missing data is handled in correlation matrix computation, the
number of samples used is returned. If `all.obs` is used the number of rows (i.e. samples)
of the orignal data is returned. If `pairwise.complete.obs` is used the crossproduct of a
matrix indicating the non-NA values is returned as matrix. This implementation was adopted
from <code><a rd-options="WGCNA" href="/link/corAndPvalue?package=molnet&version=0.1.0&to=WGCNA" data-mini-rdoc="WGCNA::corAndPvalue">corAndPvalue</a></code>.

Networks provide a means to incorporate molecular interactions into
reasoning, but on the omics-level, they are currently mainly used to combine
genomic and proteomic information. We here present a novel network analysis
pipeline that enables integrative analysis of multi-omics data including
metabolomics. It allows for comparative conclusions between two different
conditions, such as tumor subgroups, healthy vs. disease, or generally control
vs. perturbed.
Our approach focuses on interactions and their strength instead of on node
properties and includes molecules with low abundance and unknown function. We
use correlation-induced networks that are reduced and combined to form
heterogeneous, multi-omics molecular networks. Prior information such as
metabolite-protein interactions are incorporated. A semi-local, path-based
integration step denoises the network and ensures integrative conclusions. As
case studies, we investigate differential drug response in breast cancer tumor
datasets providing proteomics, transcriptomics, phospho-proteomics and
metabolomics data and contrasting patients with different estrogen receptor
status.
Our proposed pipeline leverages multi-omics data for differential predictions,
e.g. on drug response, and includes prior information on interactions.
The case study presented in the vignette uses data published by
Krug (2020) <doi:10.1016/j.cell.2020.10.036>. The package license applies only
to the software and explicitly not to the included data.

Katharina Baum

molnet

Predicting Differential Drug Response using Multi-Omics Networks

Julian Hugo

Spoorthi Kashyap

Nataniel M<c3><bc>ller

Justus Zeinert

sample_size function

(INTERNAL) Depending on how missing data is handled in correlation matrix computation, the
number of samples used is returned. If `all.obs` is used the number of rows (i.e. samples)
of the orignal data is returned. If `pairwise.complete.obs` is used the crossproduct of a
matrix indicating the non-NA values is returned as matrix. This implementation was adopted
from <code><a rd-options='WGCNA' href='corAndPvalue'>corAndPvalue</a></code>.

sample_size: Sample size for correlation computation

Description

Usage

Arguments

Value