run_app

<p>Runs the shiny app to guide user choice adequate settings to calculate
the positivity thresholds to monitor overall survival (OS)</p>

These guidelines are meant to provide a pragmatic, yet rigorous, help to drug developers and decision makers, since they are shaped by three fundamental ingredients: the clinically determined margin of detriment on OS that is unacceptably high (delta null); the benefit on OS that is plausible given the mechanism of action of the novel intervention (delta alt); and the quantity of information (i.e. survival events) it is feasible to accrue given the clinical and drug development setting. The proposed guidelines facilitate transparent discussions between stakeholders focusing on the risks of erroneous decisions and what might be an acceptable trade-off between power and the false positive error rate.

Thibaud Coroller

monitOS

Monitoring Overall Survival in Pivotal Trials in Indolent
Cancers

Thomas Fleming

Lisa Hampson

Bharani Bharani-Dharan

Frank Bretz

Arunava Chakravartty

Evanthia Koukouli

Janet Wittes

Nigel Yateman

Emmanuel Zuber

Novartis Pharma AG

run_app function

monitOS app — run_app

monitOS app

run_app: monitOS app

Description

Usage

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Value