example

<p>A matrix contains four columns: the 1st (2nd) column contains the estimated genetic effects on the outcome (exposure); the 3rd (4th) column contains the estimated standard errors of the estimated genetic effects on the outcome (exposure).</p>

The penalized inverse-variance weighted (pIVW) estimator is a Mendelian randomization method for estimating the causal effect of an exposure variable on an outcome of interest based on summary-level GWAS data. The pIVW estimator accounts for weak instruments and balanced horizontal pleiotropy simultaneously. See Xu S., Wang P., Fung W.K. and Liu Z. (2022) <doi:10.1111/biom.13732>.

Siqi Xu

example: Data example

Description

Arguments