modlib_pk

Facilitates simulation from hierarchical, ordinary
differential equation (ODE) based models typically employed in drug development.
A model specification file is created consisting of R and C++ code that
is parsed, compiled, and dynamically loaded into the R session. Input data are
passed in and simulated data are returned as R objects. A dosing event engine
allows interventions (bolus and infusion) to be managed separately from the
model code. Differential equations are solved with the 'DLSODA' routine
in 'ODEPACK' (<https://computation.llnl.gov/casc/odepack/>).

Kyle T Baron

mrgsolve

Simulate from ODE-Based Population PK/PD and Systems
Pharmacology Models

Alan C Hindmarsh

Linda R Petzold

Bill Gillespie

Charles Margossian

Devin Pastoor

Metrum Research Group LLC 

modlib_pk function

All pk models have two extravascular dosing compartments and potential for linear and nonlinear clearance.<ul>
<li><code>pk1cmt</code>: one compartment pk model</li>
<li><code>pk2cmt</code>: two compartment pk model</li>
<li><code>pk3cmt</code>: three compartment pk model</li>
</ul>

Model description

modlib: Pharmacokinetic models. — modlib_pk

modlib: Pharmacokinetic models.

modlib_pk: modlib: Pharmacokinetic models.

Description

Arguments

Value

Model description

Details