modlib_pkpd

modlib: Pharmacokinetic / pharmacodynamic models.

Facilitates simulation from hierarchical, ordinary
differential equation (ODE) based models typically employed in drug development.
A model specification file is created consisting of R and C++ code that
is parsed, compiled, and dynamically loaded into the R session. Input data are
passed in and simulated data are returned as R objects. A dosing event engine
allows interventions (bolus and infusion) to be managed separately from the
model code. Differential equations are solved with the 'DLSODA' routine
in 'ODEPACK' (<https://computation.llnl.gov/casc/odepack/>).

Kyle T Baron

mrgsolve

Simulate from ODE-Based Population PK/PD and Systems
Pharmacology Models

Alan C Hindmarsh

Linda R Petzold

Bill Gillespie

Charles Margossian

Devin Pastoor

Metrum Research Group LLC 

modlib_pkpd function

<ul>
<li><code>irm1</code> inhibition of response production</li>
<li><code>irm2</code> inhibition of response loss</li>
<li><code>irm3</code> stimulation of response production</li>
<li><code>irm4</code> stimulation of response loss</li>
<li><code>pd_effect</code> effect compartment model</li>
<li><code>emax</code> sigmoid emax model</li>
</ul>

Model description

modlib: Pharmacokinetic / pharmacodynamic models. — modlib_pkpd

modlib: Pharmacokinetic / pharmacodynamic models.

modlib_pkpd: modlib: Pharmacokinetic / pharmacodynamic models.

Description

Arguments

Model description

Details