realize_addl

realize_addl.data.frame

realize_addl.ev

<p>a <code>data_set</code> data frame or an <code>ev</code> object (see details)</p>

<p>Make addl doses explicit in an event object or data set.</p>

Facilitates simulation from hierarchical, ordinary
differential equation (ODE) based models typically employed in drug development.
A model specification file is created consisting of R and C++ code that
is parsed, compiled, and dynamically loaded into the R session. Input data are
passed in and simulated data are returned as R objects.  A dosing event engine
allows interventions (bolus and infusion) to be managed separately from the
model code. Differential equations are solved with the 'DLSODA' routine
in 'ODEPACK' (<https://computation.llnl.gov/casc/odepack/>).

Kyle T Baron

mrgsolve

Simulate from ODE-Based Population PK/PD and Systems
Pharmacology Models

Alan C Hindmarsh

Linda R Petzold

Bill Gillespie

Charles Margossian

Devin Pastoor

Metrum Research Group LLC 

realize_addl function

Make addl doses explicit in an event object or data set. — realize_addl

Make addl doses explicit in an event object or data set.

realize_addl: Make addl doses explicit in an event object or data set.

Description

Usage

Arguments

Details