modlib: PK/PD Model parameters, compartments, and output variables
EV1, EV2: extravascular dosing compartments
CENT: central PK compartment
PERIPH: peripheral PK compartment
PERIPH2: peripheral PK compartment 2
RESP: response PD compartment (irm models)
CP: concentration in the central compartment (CENT/VC)
RESP: response (emax model)
KA1, KA2: first order absorption rate constants
from first and second extravascular compartment (1/time)
CL: clearance (volume/time)
VC: volume of distribution, central compartment (volume)
VP: volume of distribution, peripheral compartment
(volume)
VP2: volume of distribution, peripheral compartment 2
(volume)
Q: intercompartmental clearance (volume/time)
Q2: intercompartmental clearance 2 (volume/time)
VMAX: maximum rate, nonlinear process (mass/time)
KM: Michaelis constant (mass/volume)
K10: elimination rate constant (1/time); CL/VC
K12: rate constant for transfer to peripheral compartment
from central (1/time); Q/VC
K21: rate constant for transfer to central compartment from
peripheral (1/time); Q/VP
E0: baseline effect (emax model)
EMAX, IMAX: maximum effect (response)
EC50, IC50: concentration producing 50 percent of
effect (mass/volume)
KIN: zero-order response production rate (irm models)
(response/time)
KOUT: first-order response elimination rate (irm models)
(1/time)
n: sigmoidicity factor
KEO: rate constant for transfer to effect compartment
(1/time)