modlib_tmdd

modlib: Target mediated disposition model

Fast simulation from ordinary differential equation
(ODE) based models typically employed in quantitative pharmacology and
systems biology.

Kyle T Baron

mrgsolve

Simulate from ODE-Based Models

Bill Gillespie

Charles Margossian

Devin Pastoor

Bill Denney

Dilawar Singh

Felicien Le Louedec

Timothy Waterhouse

Metrum Research Group 

modlib_tmdd function

<ul>
<li><code>KEL</code>: elimination rate constant</li>
<li><code>KTP</code>: tissue to plasma rate constant</li>
<li><code>KPT</code>: plasma to tissue rate constant</li>
<li><code>VC</code>: volume of distribution</li>
<li><code>KA1</code>, <code>KA2</code>: absorption rate constants</li>
<li><code>KINT</code>: internalization rate constant</li>
<li><code>KON</code>: association rate constant</li>
<li><code>KOFF</code>: dissociation rate constant</li>
<li><code>KSYN</code>: target synthesis rate</li>
<li><code>KDEG</code>: target degredation rate constant</li>
</ul>

Parameters

<ul>
<li><code>CENT</code>: unbound drug in central compartment</li>
<li><code>TISS</code>: unbound drug in tissue compartment</li>
<li><code>REC</code>: concentration of target</li>
<li><code>RC</code>: concentration of drug-target complex</li>
<li><code>EV1</code>, <code>EV2</code>: extravascular dosing compartments</li>
</ul>

Compartments

<ul>
<li><code>CP</code>: unbound drug in the central compartment</li>
<li><code>TOTAL</code>: total concentration of target (complexed and uncomplexed)</li>
</ul>

modlib_tmdd: modlib: Target mediated disposition model

Description

Arguments

Parameters

Compartments

Output variables