Functions to calculate hazard and survival function of Multi-Stage Clonal Expansion Models used in cancer epidemiology. For the Two-Stage Clonal Expansion Model an exact solution is implemented assuming piecewise constant parameters, see Heidenreich, Luebeck, Moolgavkar (1997) tools:::Rd_expr_doi("10.1111/j.1539-6924.1997.tb00878.x"). Numerical solutions are provided for its extensions, see also Little, Vineis, Li (2008) tools:::Rd_expr_doi("10.1016/j.jtbi.2008.05.027").
Maintainer: Cristoforo Simonetto cristoforo.simonetto@ph.tum.de (ORCID)
Other contributors:
Jan Christian Kaiser [contributor]