fev: FEV1 measurements from lung transplant recipients
Description
A series of measurements of the forced expiratory volume in one
second (FEV1) from lung transplant recipients, from six months onwards
after their transplant.format
A data frame containing 5896 rows. There are 204 patients, the rows
are grouped by patient number and ordered by days after transplant.
Each row represents an examination and containing an additional
covariate.
rll{
ptnum (numeric) Patient identification number.
days (numeric) Examination time (days after
transplant).
fev (numeric) Percentage of baseline FEV1. A code of
999 indicates the patient's date of death.
acute (numeric) 0/1 indicator for whether the patient
suffered an acute infection or rejection
within 14 days of
the visit.
}source
Papworth Hospital, U.K.Details
A baseline "normal" FEV1 for each individual is calculated using
measurements from the first six months after
transplant. After six months, as presented in this dataset, FEV1 is
expressed as a percentage of the baseline value. FEV1 is monitored to diagnose bronchiolitis obliterans syndrome (BOS),
a long-term lung function decline, thought to be a form of chronic
rejection. Acute rejections and infections also affect the lung
function in the short term.
References
Jackson, C.H. and Sharples, L.D. Hidden Markov models for the
onset and progression of bronchiolitis obliterans syndrome in lung
transplant recipients Statistics in Medicine, 21(1): 113--128
(2002).