multcomp (version 1.2-12)

cml: Chronic Myelogenous Leukemia survival data.

Description

Survival in a randomised trial comparing three treatments for Chronic Myelogeneous Leukemia (simulated data).

Usage

data("cml")

source

R. Hehlmann, H. Heimpel, J. Hasford, H.J. Kolb, H. Pralle, D.K. Hossfeld, W. Queisser, H. Loeffler, A. Hochhaus, B. Heinze (1994), Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia. The German CML study group. Blood 84(12):4064-4077.

Details

The data are simulated according to structure of the data by the German CML Study Group used in Hehlmann (1994).

Examples

if (require("coxme")) {
    data("cml")
    ### one-sided simultaneous confidence intervals for many-to-one 
    ### comparisons of treatment effects concerning time of survival 
    ### modeled by a frailty Cox model with adjustment for further 
    ### covariates and center-specific random effect.
    cml_coxme <- coxme(Surv(time, status) ~ treatment + sex + age + riskgroup + (1|center), data = cml)
    glht_coxme <- glht(model = cml_coxme, linfct = mcp(treatment = "Dunnett"), alternative = "greater")
    ci_coxme <- confint(glht_coxme)
    exp(ci_coxme$confint)[1:2,]
}