mutSignatures (version 1.2)

decipherMutationalProcesses: Decipher Mutational Processes Contributing to a Collection of Genomic Mutations

Description

Cancer cells accumulate DNA mutations as result of DNA damage and DNA repair processes. This computational framework allows to decipher mutational processes from cancer-derived somatic mutational catalogs

Usage

decipherMutationalProcesses(input, params)

Arguments

input

object (list) including a Mutation Count matrix. This is the output of a setMutCountObject() call

params

object (list) including the parameters required for running the analysis. This is the output of a setMutClusterParams() call

Value

list including all results of the analysis. The extracted signatures (processes) are included in the "processes" element of the list. The relative contribution of each signature in each sample is summarized in the "exposures" element

References

More info at: http://www.biotechworld.it/bioinf/2017/01/22/mutsignatures/

Examples

# NOT RUN {
tmp <- getTestRunArgs(2)
decipherMutationalProcesses(input = tmp$mutCount.obj, params = tmp$params)
# }