mutSignatures (version 1.2)

mutSignatures-package: Computational Framework for Deciphering Cancer Mutational Signatures

Description

Accumulation of DNA mutations is a hallmark of cancer. Cancer cells accumulate DNA mutations as result of DNA damage and DNA repair processes. This computational framework allows to characterize mutational signatures from cancer-derived somatic mutational catalogs

Details

Please, cite the following article when using this software: Fantini D et al, Mol Biol Cell. 2017 Jan 1;28(1):192-200. More info at: http://www.biotechworld.it/bioinf/2017/01/22/mutsignatures/ Software developed in the Meeks Lab, Dept. of Urology, Northwestern University, Chicago, USA This is a R implementation of the original MATLAB framework described here: Cell Rep. 2013 Jan 31;3(1):246-59.

Examples

# NOT RUN {
  citation()
  
# }
# NOT RUN {
  tmp <- getTestRunArgs()
  result <- extractSignatures(mutCountMatrix = tmp$mutCount.obj$mutCounts, params = tmp$params)
  result
  plotSignatureExposures(results)
  
# }